A skilled "handyman" who takes on even the most dangerous demons like it's nothing. As the son of the demonic knight Sparda, Dante has always been a formidable fighter, but his work over the years has honed both his body and his mind even further.
He wields a demon sword, as well as two handguns, and is at the top of his game when it comes to his chosen weapons. Dante follows in his father's legendary footsteps as he carries out his missions. While on a job at Dumary Island, he is confronted with the revival of a long-sealed demon king.

A woman who lives to protect Dumary Island, a place of great holiness and great evil. As the ritual chief of the Vie de Marli guardian clan, Lucia has the power to interact with and even destroy the island's strange gods. She senses the coming destination and takes measures to prevent it. Lucia is in fact a Secretary demon, created by Arius. He attempted to dispose of her, but Matier managed to save her.

Lucia's mother and a member of the Vie de Marli guardian clan. She raised Lucia as a warrior, teaching her how to fight and use weapons. Matier's age is unknown, but in the present, the bulk of the clan's duties fall to Lucia. Long ago, Matier fought a terrible demon alongside Dante's father, Sparda.

The CEO of the international corporation Uroboros, and a powerful sorcerer. Uroboros is primarily a mining and construction company, and it has expanded aggressively all over the world. Arius' reach has now spread to Dumary Island as well, where his efforts to release a sealed demon king are disguised as innocent corporate activities. He manages to warp space on the island and open a door to the demon world.